![]() ![]() ![]() 716 patients underwent randomization in which 360 were assigned to the standard regimen MAGIC with ECF/ECX (3 weekly cycle of Epirubicin=50mg/m2 D1, Cisplatin= 60mg/m2 D1, 5-FU= 200mg/m2 continous IV infusion D1-D21 or Oral Capecitabine= 1250mg/m2 BID D1-D21 on investigator's choice) and 356 to FLOT ( biweekly cycle of Docetaxel= 50mg/m2 D1, Oxaliplatin= 85mg/m2 D1, Leucovorin 200mg/m2 D1 and 5-FU= 2600mg/m2 24 hour infusion D1). Recently, randomized phase II/III trial of FLOT4 for locally advanced resectable gastric (44%) or GEJ (siewert I-II-III, 56%) non-metastatic adenocarcinoma was published in Lancet Journal (5). Significant clinical responses were seen in patients with more acceptable safety profile than classical DCF. Eventually, the FLOT regimen was evaluated in phase II trial in metastatic or unresectable gastric cancer patients (4). The classical DCF (taxane + platinum + fluoropyrimidine) regimen was associated with high toxicity profile with tolerability issues, failing to perform betterment than doublets, frontline. The role of Docetaxel has been investigated in gastric cancer in different settings and exerted significant activity in clinical trials (3). Both MAGIC and FNCLCC/FFCD demonstrated a significant improvement in OS in pts treated with perioperative chemotherapy regardless of anatomical location of tumor (GEJ or gastric) making this strategy a new standard of care in Europe. Control group underwent surgery alone and there was significant improvement in OS seen in chemotherapy group (38% vs 24%) with HR for death of 0.69 (95% CI, 0.50-0.89, p= 0.02). It has similar design to MAGIC trial and patient received 2-3 cycles of Cisplatin and 5-Flourouracil before and after surgery. Another landmark phase III trial done was FNCLCC/FFCD (2). ![]() The experimental arm showed significant improvement in 5 year OS (36%) with hazard ratio (HR) for death of 0.75 (95% Confidence interval (CI) 0.60-0.93, p=0.0009) as compared to surgery alone (23%). Patients received 3 cycles of ECF/ECX in pre and post operative settings. MAGIC trial is the first landmark trial, which showed overall survival (OS) improvement with perioperative chemotherapy in resectable gastric (74%), GEJ junction (11-12%) and lower esophageal adenocarcinoma (14-15%) (1). In fact, various trials showed an improvement in overall survival (OS) by using a perioperative treatment if compared with surgery. Multimodal approach represents the standard of care for treatment of resectable oesophageal and gastric cancer patients today, especially in the case of GEJ and cardial tumors. This dialog states that the the app will continue running in the background via your Mac’s menubar.Gastroesophageal junction (GEJ) and gastric adenocarcinoma prognosis remains poor despite of recent advancement in therapies. ![]() The first time you close the Preferences menu, you will be presented with the following dialog: Hide Trail When Mouse is Not Moving: Toggle this on/off in order to either have a permanent trail animation, even when the mouse is not moving, or to then disable the trail animation when there is no mouse movement. Trail Length: Drag the bar across to determine how short or long you would like your trail effect to be. Trail Style: Click on this drop down menu to see a list of all the trail styles that you can choose from, as seen below. Enabling this will mean that the popup dialog won’t appear every time you launch the app.Įnable Mouse Trail: Toggling this function on/off will determine whether your mouse pointer will have a trail or not. Hide Preferences on Startup: Magic Trail always launches the Welcome/Preferences dialog whenever the app is launched. Start at Login: Enable this option to have Magic Trail launch at login, every time you start your Mac. Toggle with Hotkey: This lets you assign a hotkey in order to enable or disable the magic trail effect quickly. To change features within the app, we suggest you click on the Preferences menu at this point (you can also access the Preferences menu by right clicking the Magic Trail menubar icon on the top of your Mac’s screen). Upon first launch, you are presented with the following welcome screen: The app functions as a menubar app, running on the top of your screen. It’s simple, quirky and slick, working even with multiple monitors. Magic Trail is a fun app crafted to add special trailing effects to your mouse pointer. ![]()
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